MovDisordV3, Main, Exploration, bibRecord, 003013

Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts

Identifieur interne : 003013 ( Main/Exploration ); précédent : 003012; suivant : 003014

Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts

Auteurs : Shalom Michaeli [États-Unis] ; Gülin Öz [États-Unis] ; Dennis J. Sorce [États-Unis] ; Michael Garwood [États-Unis] ; Kamil Ugurbil [États-Unis] ; Stacy Majestic [États-Unis] ; Paul Tuite [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-02-15.

RBID : ISTEX:6F1A503DEEFA2E3F2DE2C9151950119FB5ADF403

Descripteurs français

Pascal (Inist)
- Fer, Homme, Imagerie RMN, Parkinson maladie, Système nerveux pathologie.
Wicri :
- topic : Fer, Homme.

English descriptors

KwdEn :
- Aged, Brain Mapping, Case-Control Studies, Female, Human, Humans, Iron, Iron (metabolism), Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Neurons (pathology), Nuclear magnetic resonance imaging, Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson disease, Relaxation (physiology), T1ρ and T2ρ MRI, iron load and distribution, neuronal loss.
MESH :
- chemical , metabolism : Iron.
- metabolism : Parkinson Disease.
- pathology : Neurons, Parkinson Disease.
- physiology : Relaxation.
- Aged, Brain Mapping, Case-Control Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.

Abstract

Postmortem demonstration of increased iron in the substantia nigra (SN) is a well‐appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals, which are thought to play a role in dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed to show significant in vivo differences in SN iron levels in subjects with PD versus control subjects. This finding may be due to the limitations in tissue contrasts achievable with conventional T1‐ and T2‐weighted MRI sequences that have been used. With the recent development of novel rotating frame transverse (T2ρ) and longitudinal (T1ρ) relaxation MRI methods that appear to be sensitive to iron and neuronal loss, respectively, we embarked on a study of 8 individuals with PD (Hoehn & Yahr, Stage II) and 8 age‐matched control subjects. Using these techniques with a 4T MRI magnet, we assessed iron deposits and neuronal integrity in the SN. First, T2ρ MRI, which is reflective of iron‐related dynamic dephasing mechanisms (e.g., chemical exchange and diffusion in the locally different magnetic susceptibilities), demonstrated a statistically significant difference between the PD and control group, while routine T2 MRI did not. Second, T1ρ measurements, which appear to reflect upon neuronal count, indicated neuronal loss in the SN in PD. We show here that sub‐millimeter resolution T1ρ and T2ρ MRI relaxation methods can provide a noninvasive measure of iron content as well as evidence of neuronal loss in the midbrain of patients with PD. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/6F1A503DEEFA2E3F2DE2C9151950119FB5ADF403/fulltext/pdf

DOI: 10.1002/mds.21227

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Postmortem demonstration of increased iron in the substantia nigra (SN) is a well‐appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals, which are thought to play a role in dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed to show significant in vivo differences in SN iron levels in subjects with PD versus control subjects. This finding may be due to the limitations in tissue contrasts achievable with conventional T1‐ and T2‐weighted MRI sequences that have been used. With the recent development of novel rotating frame transverse (T2ρ) and longitudinal (T1ρ) relaxation MRI methods that appear to be sensitive to iron and neuronal loss, respectively, we embarked on a study of 8 individuals with PD (Hoehn & Yahr, Stage II) and 8 age‐matched control subjects. Using these techniques with a 4T MRI magnet, we assessed iron deposits and neuronal integrity in the SN. First, T2ρ MRI, which is reflective of iron‐related dynamic dephasing mechanisms (e.g., chemical exchange and diffusion in the locally different magnetic susceptibilities), demonstrated a statistically significant difference between the PD and control group, while routine T2 MRI did not. Second, T1ρ measurements, which appear to reflect upon neuronal count, indicated neuronal loss in the SN in PD. We show here that sub‐millimeter resolution T1ρ and T2ρ MRI relaxation methods can provide a noninvasive measure of iron content as well as evidence of neuronal loss in the midbrain of patients with PD. © 2006 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts

Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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